The Mesterolone hormone is not estrogenic. It does not aromatize and it carries no progestin nature. As a result, the side effects of Proviron will not include any related effects such as gynecomastia or excess water retention. Such adverse effects are impossible with this steroid. This will also greatly reduce the risk of high blood pressure as high blood pressure associated with anabolic steroid use is often due to extreme water retention. In fact, Proviron should provide an anti-estrogenic effect by preventing testosterone to estrogen conversion or at least tremendously slow it down.
The influences of two toxins, phomopsin and ivalin, which are reported to exhibit carcinogenic and antitumor activities, respectively, were studied on steroid hormone receptor binding. A mycotoxic carcinogenic fraction A (phomopsin) was isolated from Phomopsis leptostromiformis. The antitumor sesquiterpene lactone ivalin was obtained from the "vomiting bush" Geigeria. Competitive binding analyses were conducted with radiolabeled steroid ligands and unlabeled toxins. No effect of these toxins was observed on either the binding capacity or on the rate of steroid association of [3H]-estradiol-17 beta, [3H]promegestone (R5020), and [3H]dexamethasone to their respective receptors in cytosol of human breast cancer and rat liver. The concentrations of phomopsin and ivalin varied between nM to 14 micron in the competitive binding assays. These data suggest the carcinogenic and antitumor activities of these toxins do not involve association with steroid hormone receptors.