Oxypregnane steroidal glycoside side effects

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This is from my experience with Plexus. I took it on and off for a couple of months, but last month I decided to stick with it. I got my bag of Plexus Slim shakes at the start of August 2014. My mom used to be an ambassador for them but since she’s not a salesman she dropped out, so that is how I heard of it. Originally I ordered some to help her out. Anyway, come August 2014, I started taking it and I do one packet a day first thing in the morning before I eat anything and wait 30 mins before I eat anything after taking the shake. Anyway, about a week into it, I started getting severe diarrhea, and serious stomach aches and cramps and gas, which I figured it was the way it works, it gets rid of the nasty stuff in my body. Well, after a week of severe diarrhea, I continued on having it, but this time with blood. I was going to the bathroom at least 6 – 8 times a day. It is now August 21st, 2014 and I stopped taking Plexus slim Saturday August 16 and have not had it since and I am still dealing with severe diarrhea and blood. The stomach cramps have stopped, but now I’m starting to get a little worried. I’ve been to the bathroom at least 6 times today with nothing but serious diarrhea and some of it with blood. If it doesnt stop, I’m going to have to go to the doctor. So if you’re planning on taking this, please be careful because as you can see, it has it’s side effects. It did help me lose weight, but I think I can find a better product to help me lose weight without the severe diarrhea.

Hoodia is prepared from the stems and roots of the succlent plant Hoodia gordonii found in the Kalahari Desert and claimed to be used traditionally by Kalahari Bushmen to reduce their hunger and thirst during long hunts.  However, it may be more accurate to say that Hoodia is a food source and was used mostly to quench thirst.  Nevertheless, scientific studies in laboratory animals have shown that extracts of hoodia containing an oxypregnane steroidal glycoside have appetite suppressing activity.  The traditional use and subsequent laboratory findings led to the marketing of hoodia as a weight loss agent.  Dried extracts of stems and roots are used to make powders, capsules, chewable tablets and liquid preparations for making teas.  Hoodia is often combined with other purported weight loss herbs such as green tea and chromium picolinate.  To date, there have been no prospective controlled trials demonstrating an effect of hoodia on food intake or weight management in humans.  In uncontrolled studies, use of hoodia has been reported to have no adverse side effects.

P57AS3 (P57), an oxypregnane steroidal glycoside, is known to be responsible for the appetite suppressing activity of HOODIA GORDONII, a dietary supplement used for weight loss. In this study, bioavailability, pharmacokinetics, and tissue distribution of P57 were determined in CD1 female mice after administration of a single dose of enriched methanolic extract of HOODIA GORDONII (equivalent to a dose of 25 mg of P57/kg) by oral gavage or a single dose of purified P57 (25 mg/kg) intravenously. The level of P57 in plasma and tissues (brain, liver, kidney, and intestine) was determined by UPLC-MS. After oral administration of HOODIA extract, the peak plasma level of P57 was achieved in  h. Upon intravenous administration, the plasma clearance rate of P57 was  L/h/kg. P57 was rapidly distributed and eliminated from the tissues within 4 hours. The level of tissue distribution was highest in the kidney followed by liver and brain. Upon oral administration, P57 was not detected in the brain and a very low concentration was seen in the intestine, kidney, and liver. Tissue/plasma ratio was for brain, for liver, and for kidney with IV route and for intestine, for liver, and for kidney with oral route. The half-life of the elimination phase was similar with both routes. The oral bioavailability was  % and the half-life of the absorption phase was  h. In conclusion, P57 showed moderate bioavailability and was eliminated rapidly.

Oxypregnane steroidal glycoside side effects

oxypregnane steroidal glycoside side effects

P57AS3 (P57), an oxypregnane steroidal glycoside, is known to be responsible for the appetite suppressing activity of HOODIA GORDONII, a dietary supplement used for weight loss. In this study, bioavailability, pharmacokinetics, and tissue distribution of P57 were determined in CD1 female mice after administration of a single dose of enriched methanolic extract of HOODIA GORDONII (equivalent to a dose of 25 mg of P57/kg) by oral gavage or a single dose of purified P57 (25 mg/kg) intravenously. The level of P57 in plasma and tissues (brain, liver, kidney, and intestine) was determined by UPLC-MS. After oral administration of HOODIA extract, the peak plasma level of P57 was achieved in  h. Upon intravenous administration, the plasma clearance rate of P57 was  L/h/kg. P57 was rapidly distributed and eliminated from the tissues within 4 hours. The level of tissue distribution was highest in the kidney followed by liver and brain. Upon oral administration, P57 was not detected in the brain and a very low concentration was seen in the intestine, kidney, and liver. Tissue/plasma ratio was for brain, for liver, and for kidney with IV route and for intestine, for liver, and for kidney with oral route. The half-life of the elimination phase was similar with both routes. The oral bioavailability was  % and the half-life of the absorption phase was  h. In conclusion, P57 showed moderate bioavailability and was eliminated rapidly.

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