Patients treated with methylprednisolone had a higher rate of return to normal vision in visual fields (p = ) and contrast sensitivity (p = ), with a trend towards improved visual acuity (p = ) compared to placebo. At 6 months, patients in the methylprednisolone group experienced better contrast sensitivity (p = ) and color vision (p = ), with no differences noted in visual acuity (p = ). There were no significant differences in the rates of recovery for oral prednisone patients compared to placebo in all measures of vision (p > ). By 24 months, 20 (13%) patients in the methylprednisolone group, 42 (27%) patients in the oral prednisone group, and 24 (15%) patients in the placebo group had experienced ≥1 new episode of optic neuritis. The oral prednisone group had a higher rate of new episodes of optic neuritis compared with placebo (RR , 95%CI -).
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Ages Eligible for Study: 18 Years to 46 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria The major eligibility criteria for enrollment into the ONTT included the following:
Edsel Ing, MD, MPH, FRCSC Associate Professor, Department of Ophthalmology and Vision Sciences, University of Toronto Faculty of Medicine; Active Staff, Michael Garron Hospital (Toronto East Health Network); Consulting Staff, Hospital for Sick Children and Sunnybrook Hospital, Canada
Edsel Ing, MD, MPH, FRCSC is a member of the following medical societies: American Academy of Ophthalmology , American Association for Pediatric Ophthalmology and Strabismus , American Society of Ophthalmic Plastic and Reconstructive Surgery , Canadian Medical Association , Canadian Ophthalmological Society , Canadian Society of Oculoplastic Surgery , Chinese Canadian Medical Society, European Society of Ophthalmic Plastic and Reconstructive Surgery, North American Neuro-Ophthalmology Society , Ontario Medical Association , Royal College of Physicians and Surgeons of Canada , Statistical Society of Canada
Disclosure: Nothing to disclose.