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Patients treated with methylprednisolone had a higher rate of return to normal vision in visual fields (p = ) and contrast sensitivity (p = ), with a trend towards improved visual acuity (p = ) compared to placebo. At 6 months, patients in the methylprednisolone group experienced better contrast sensitivity (p = ) and color vision (p = ), with no differences noted in visual acuity (p = ). There were no significant differences in the rates of recovery for oral prednisone patients compared to placebo in all measures of vision (p > ). By 24 months, 20 (13%) patients in the methylprednisolone group, 42 (27%) patients in the oral prednisone group, and 24 (15%) patients in the placebo group had experienced ≥1 new episode of optic neuritis. The oral prednisone group had a higher rate of new episodes of optic neuritis compared with placebo (RR , 95%CI -).

Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:   18 Years to 46 Years   (Adult) Sexes Eligible for Study:   All Accepts Healthy Volunteers:   No Criteria The major eligibility criteria for enrollment into the ONTT included the following:

Edsel Ing, MD, MPH, FRCSC  Associate Professor, Department of Ophthalmology and Vision Sciences, University of Toronto Faculty of Medicine; Active Staff, Michael Garron Hospital (Toronto East Health Network); Consulting Staff, Hospital for Sick Children and Sunnybrook Hospital, Canada

Edsel Ing, MD, MPH, FRCSC is a member of the following medical societies: American Academy of Ophthalmology , American Association for Pediatric Ophthalmology and Strabismus , American Society of Ophthalmic Plastic and Reconstructive Surgery , Canadian Medical Association , Canadian Ophthalmological Society , Canadian Society of Oculoplastic Surgery , Chinese Canadian Medical Society, European Society of Ophthalmic Plastic and Reconstructive Surgery, North American Neuro-Ophthalmology Society , Ontario Medical Association , Royal College of Physicians and Surgeons of Canada , Statistical Society of Canada

Disclosure: Nothing to disclose.

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