Crisaborole topical ointment, 2% (formerly known as AN2728) is a benzoxaborole, nonsteroidal, topical, anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor investigational compound that recently completed phase 3 studies for the treatment of mild to moderate atopic dermatitis (AD). The unique configuration of boron within the crisaborole molecule enables selective targeting and inhibition of PDE4, an enzyme that converts the intracellular second messenger 3'5'-cyclic adenosine monophosphate (cAMP) into the active metabolite adenosine monophosphate (AMP). By inhibiting PDE4 and thus increasing levels of cAMP, crisaborole controls inflammation. The use of boron chemistry enabled synthesis of a low-molecular-weight compound (251 daltons), thereby facilitating effective penetration of crisaborole through human skin. In vitro experiments showed that crisaborole inhibits cytokine production from peripheral blood mononuclear cells in a pattern similar to other PDE4 inhibitors and distinct from corticosteroids. Crisaborole also displayed topical anti-inflammatory activity in a skin inflammation model. Once crisaborole reaches systemic circulation after topical application, it is metabolized to inactive metabolites. This limits systemic exposure to crisaborole and systemic PDE4 inhibition. In phase 1 and 2 clinical studies, crisaborole ointment, 2% was generally well tolerated and improved AD disease severity scores, pruritus, and all other AD signs and symptoms. Two large, randomized, controlled, phase 3, pivotal clinical trials assessing the efficacy and safety of crisaborole topical ointment, 2% in children, adolescents, and adults with mild to moderate AD were recently completed with positive results.
Purepotions have developed a natural hair care regime for those who want to use only the mildest and gentlest of botanical ingredients on their crowning glory! Kind to skin and kind to the planet, our Natural Shampoo with chamomile and calendula and Natural Conditioner with oats and hemp seed oil are made with gentle plant-based cleansers and ingredients of natural origin such as herbal tinctures, organic oils and plant extracts. They are free from potentially irritating or toxic additives such as perfumes, petrochemicals, parabens or SLS/SLES, so are also suitable for those prone to scalp psoriasis, eczema or dry, itchy, flaky scalps.
The range is completed by our popular Scalp Oil with tea-tree, borage and rosemary, which nourishes and conditions itchy, flaky scalps. This 100% natural blend of oils is perfect for overnight application to give your hair a really intensive conditioning treatment and keep your scalp hydrated and healthy.