OneRNA™ can assist you in selecting the right patients for your clinical trial. Reducing the number of different test to ONE, without compromising the number of markers you want to include. In fact you can have it all +20,000 RNA’s in ONE assay. Furthermore adding a new marker is a simple update to our cloud-based software which we can do retrospectively. As such, OneRNA™is uniquely able to keep pace with rapidly evolving clinical research and cancer drug development. Finally we can help you focus on the right indication, expand your label on existing drugs, and create responder algorithms rather than relying on one marker as a companion diagnostic.
Neural injections of Bromodeoxyuridine (BrdU) were applied to males of both groups to test for neurogenesis . Analysis showed that testosterone and dihydrotestosterone regulated adult hippocampal neurogenesis (AHN). Adult hippocampal neurogenesis was regulated through the androgen receptor in the wild-type male rats, but not in the TMF male rats. To further test the role of activated androgen receptors on AHN, flutamide , an antiandrogen drug that competes with testosterone and dihydrotestosterone for androgen receptors , and dihydrotestosterone were administered to normal male rats. Dihydrotestosterone increased the number of BrdU cells, while flutamide inhibited these cells.
In 1941 several members of TIGR were condemned for espionage and terrorism at the Second Trieste trial ; four of them ( Viktor Bobek , Ivan Ivančič , Simon Kos and Ivan Vadnal ) were executed in Villa Opicina near Trieste the same year, jointly with the Communist activist Pinko Tomažič . By the time of the Axis invasion of Yugoslavia in April 1941, most of the organization was already dismantled by both Italian and Nazi German secret police and most of its prominent members either sent to concentration camps , killed or exiled .