Muscle protein anabolic response

Increased dietary LCn-3PUFA (long-chain n-3 polyunsaturated fatty acid) intake stimulates muscle protein anabolism in individuals who experience muscle loss due to aging or cancer cachexia. However, it is not known whether LCn-3PUFAs elicit similar anabolic effects in healthy individuals. To answer this question, we evaluated the effect of 8 weeks of LCn-3PUFA supplementation (4 g of Lovaza®/day) in nine 25-45-year-old healthy subjects on the rate of muscle protein synthesis (by using stable isotope-labelled tracer techniques) and the activation (phosphorylation) of elements of the mTOR (mammalian target of rapamycin)/p70S6K (p70 S6 kinase) signalling pathway during basal post-absorptive conditions and during a hyperinsulinaemic-hyperaminoacidaemic clamp. We also measured the concentrations of protein, RNA and DNA in muscle to obtain indices of the protein synthetic capacity, translational efficiency and cell size. Neither the basal muscle protein fractional synthesis rate nor basal signalling element phosphorylation changed in response to LCn-3PUFA supplementation, but the anabolic response to insulin and amino acid infusion was greater after LCn-3PUFA [. the muscle protein fractional synthesis rate during insulin and amino acid infusion increased from ± to ±%/h and the phospho-mTOR (Ser2448) and phospho-p70S6K (Thr389) levels increased by ∼50%; all P<]. In addition, the muscle protein concentration and the protein/DNA ratio (. muscle cell size) were both greater (P<) after LCn-3PUFA supplementation. We conclude that LCn-3PUFAs have anabolic properties in healthy young and middle-aged adults.

I typically have nonfat to 1% low-fat cottage cheese or casein protein shake with skim milk and honey before hitting the sack. I sometimes even combine honey with cinnamon. The reason for this is two fold. The first is contrary to what you may believe, a teaspoon of raw honey can help burn fat and improve sleep because the honey gets converted into serotonin by the brain and helps production of the sleep hormone melatonin. The second being cinnamon, in addition to being a powerful anti-oxidant, imitates insulin and helps prevents too much fatty triglycerides from accumulating in the blood.

Combat from MusclePharm is designed to keep feeding your muscles for up to eight hours. For people that demand a lot of protein and have a high intensity workout schedule then this could be the protein that you need. This Whey Protein is actually a blend containing Whey Isolates, hydrolyzed Whey and Whey Concentrates. This formula is designed to ensure your muscles are fed for up to eight hours. There is also BCAA’s present in the formula to ensure your muscles get everything they need to grow and help you put on lean muscle mass.

Hi Mark,
I think i might have an intolerance to whey or milk protein, after consuming an Impact whey shake with 5g Creatine mono i feel sick and nausea which lasts for 36 to 48 has happened several times now, which led to me having blood tests to check for GI problems (which came back all clear). It is having a real start stop effect on my workouts, what would be the best way of dealing with this issue.
I’ve been following you for a while now and been impressed with everything you have written, al the best.

Muscle protein anabolic response

muscle protein anabolic response

Hi Mark,
I think i might have an intolerance to whey or milk protein, after consuming an Impact whey shake with 5g Creatine mono i feel sick and nausea which lasts for 36 to 48 has happened several times now, which led to me having blood tests to check for GI problems (which came back all clear). It is having a real start stop effect on my workouts, what would be the best way of dealing with this issue.
I’ve been following you for a while now and been impressed with everything you have written, al the best.

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