A Stanford University School of Medicine meta-analysis of clinical studies on the subject published in early 2007 showed that the application of GH on healthy elderly patients increased muscle by about 2 kg and decreased body fat by the same amount.  However, these were the only positive effects from taking GH. No other critical factors were affected, such as bone density, cholesterol levels, lipid measurements, maximal oxygen consumption, or any other factor that would indicate increased fitness.  Researchers also did not discover any gain in muscle strength, which led them to believe that GH merely let the body store more water in the muscles rather than increase muscle growth. This would explain the increase in lean body mass.
Acromegaly patients, who suffer from natural growth hormone levels of up to 100 times higher than normal, have lower stamina towards physical activity than people with regular levels.  When the patients are treated and their growth hormone levels decrease, their stamina improves.  This knowledge is part of the evidence behind the new belief that athletes who use supplemental HGH to raise their levels far above average could actually decrease their exercise tolerance, and thus hurt their athletic performance.  Further backing was provided in a study done by the Danish Institute of Sports Medicine. They found cyclists of good health and endurance “were unable to complete accustomed cycling tasks after administration of exogenous hGH” and concluded that HGH can inhibit recuperation from exercise.  Participants have also been found to have lower stamina after HGH treatment along with higher rates of fatigue.