Ovarian function was investigated in 30 women with postural idiopathic edema by measuring plasma estradiol and progesterone levels between the 21st and 23rd days of the menstrual cycle . Plasma progesterone concentrations were found to be lower than 5ng/ml in 53% of the cases and lower than 10ng/ml in 83%. The ovarian dysfunction most frequently observed was inadequate corpus luteum , . progesterone deficiency with normal plasma estradiol levels. In virtually all patients the initial disorder in capillary permeability, as evaluated by Landis' test, was fully corrected by progesterone administered orally. However, clinical improvement was less marked with treatments of short duration (2-3 consecutive cycles). In view of the complex cause of the disease, combined treatments in which progesterone might well play the major role are usually required. [ Presse Med 1983 Dec 10;12(45): -62 (translated) ]
According to the Vitamin D Council , vitamin D has co-factors that the body needs in order to utilize it properly. They are: magnesium, zinc, vitamin K2, boron and a tiny amount of vitamin A. The Council goes on to report that magnesium is the most important of these co-factors. Clinically it is common for rising vitamin D levels to uncover an underlying magnesium deficiency. So if you are taking vitamin D and start to feel worse rather than better, you might be experiencing magnesium deficiency symptoms and need to increase your intake of magnesium.