In 12 normal-weight subjects, administration of XENICAL 120 mg three times a day for 16 days did not result in any change in either warfarin pharmacokinetics (both R- and S-enantiomers) or pharmacodynamics ( prothrombin time and serum Factor VII). Although undercarboxylated osteocalcin, a marker of vitamin K nutritional status, was unaltered with XENICAL administration, vitamin K levels tended to decline in subjects taking XENICAL. Therefore, as vitamin K absorption may be decreased with XENICAL, patients on chronic stable doses of warfarin who are prescribed XENICAL should be monitored closely for changes in coagulation parameters.
Anxiety, gut problems and allergies very often go hand in hand and can be very distressing. Often the root cause of the problem can be found in a damaged gut flora and a weakened gut lining which disturbs the immune system. Research has shown that probiotics has been very beneficial for those suffering from different kinds of allergies and intolerances. Serious probiotics adverse effects are extremely rare. A study in Jan 2013 showed that 8 weeks of eating probiotics decreased the level of allergic markers in the body. That study dealt with pollen allergy but the same applies to many other allergies. The study reported no side effects whatsoever. Many other studies show similar results with probiotics for allergies, depression, inflammation and gut problems. That includes basically all symptoms that you mention. One reason why probiotics works so well for all those symptoms is that the root cause is a damaged/abnormal gut causing a chain reaction that can results in many different symptoms.